Kelly, David and Coen, Robert and Kwadwo, Akuffo and Beatty, Stephen and Dennison, Jessica and Moran, Rachel and Stack, Jim and Howard, Alan N and Mulcahy, Riona and Nolan, John M (2015) Cognitive Function and Its Relationship with Macular Pigment Optical Density and Serum Concentrations of its Constituent Carotenoids. Journal of Alzheimer's disease : JAD, 48 (1). pp. 261-277. ISSN 1875-8908
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Abstract
Abstract Background: Macular pigment (MP) levels correlate with brain concentrations of lutein (L) and zeaxanthin (Z), and have also been shown to correlate with cognitive performance in the young and elderly. Objective: To investigate the relationship between MP, serum concentrations of L and Z, and cognitive function in subjects free of retinal disease with low MP (Group 1, n = 105) and in subjects with AMD (Group 2, n = 121). Methods: MP was measured using customized heterochromatic flicker photometry and dual-wavelength autofluorescence; cognitive function was assessed using a battery of validated cognition tests; serum L and Z concentrations were determined by HPLC. Results: Significant correlations were evident between MP and various measures of cognitive function in both groups (r = –0.273 to 0.261, p≤0.05, for all). Both serum L and Z concentrations correlated significantly (r = 0.187, p≤0.05 and r = 0.197, p≤0.05, respectively) with semantic (animal) fluency cognitive scores in Group 2 (the AMD study group), while serum L concentrations also correlated significantly with Verbal Recognition Memory learning slope scores in the AMD study group (r = 0.200, p = 0.031). Most of the correlations with MP, but not serum L or Z, remained significant after controlling for age, gender, diet, and education level. Conclusion: MP offers potential as a non-invasive clinical biomarker of cognitive health, and appears more successful in this role than serum concentrations of L or Z.
Item Type: | Article |
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Departments or Groups: | Macular Pigment Research Group |
Divisions: | School of Science > Department of Chemical and Life Sciences |
Depositing User: | Kwadwo Akuffo |
Date Deposited: | 02 Nov 2015 12:06 |
Last Modified: | 22 Aug 2016 10:27 |
URI: | http://repository-testing.wit.ie/id/eprint/3094 |
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