Analysis of changes in phosphorylation of receptor tyrosine kinases : Antibody arrays

Rani, Sweta and O’driscoll, Lorraine (2015) Analysis of changes in phosphorylation of receptor tyrosine kinases : Antibody arrays. Methods in Molecular Biology, 1233. pp. 15-23. ISSN 1064-3745

Full text not available from this repository. (Request a copy)

Abstract

Tyrosine kinases are mainly classifi ed into two groups, as receptor tyrosine kinase (RTK) and non-receptor tyrosine kinase (NRTK). The RTK family of transmembrane ligand-binding proteins are important mediators of the signaling cascade and includes EGFR, PDGFR (platelet-derived growth factor receptors), FGFR (fi broblast growth factor receptor) and the IR (insulin receptor). RTKs comprise 59 members and their structure includes an extracellular ligand-binding domain, a transmembrane domain, and an intracellular domain possessing the tyrosine kinase activity. This chapter focuses on antibody arrays that are basically used to analyse phosphorylation and dephosphorylation of RTKs. Antibody arrays include well-characterized antibodies for profi ling, changes in RTK expression, and comparison between normal, diseased, or treated samples.

Item Type:	Article
Additional Information:	Publisher Copyright: © Springer Science+Business Media New York 2015.
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/1300/1312
Departments or Groups:
Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:01
Last Modified:	07 Jun 2023 18:41
URI:	http://repository-testing.wit.ie/id/eprint/3630

Actions (login required)

View Item