The impact of formulation on lutein, zeaxanthin, and meso-zeaxanthin bioavailability : A randomised double-blind placebo-controlled study

Green-Gomez, Marina and Prado-Cabrero, Alfonso and Moran, Rachel and Power, Tommy and Gómez-Mascaraque, Laura G. and Stack, Jim and Nolan, John M. (2020) The impact of formulation on lutein, zeaxanthin, and meso-zeaxanthin bioavailability : A randomised double-blind placebo-controlled study. Antioxidants, 9 (8). pp. 1-15. ISSN 2076-3921

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Abstract

Lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) have been the focus of research and commercial interest for their applications in human health. Research into formulations to enhance their bioavailability is merited. This 6 month randomised placebo-controlled trial involving 81 healthy volunteers compared the bioavailability of different formulations of free L, Z, and MZ in sunflower or omega-3 oil versus L, Z, and MZ diacetates (Ld, Zd, and MZd) in a micromicellar formulation. Fasting serum carotenoids, macular pigment, and skin carotenoid score were analysed at baseline and 6 months. Serum L, Z, and MZ concentrations increased in all active interventions compared to placebo (p < 0.001 to p = 0.008). The diacetate micromicelle formulation exhibited a significantly higher mean response in serum concentrations of Z and MZ compared to the other active interventions (p = 0.002 to 0.019). A micromicellar formulation with solubilised Z and MZ diacetates is a promising technology advancement that enhances the bioavailability of these carotenoids when compared to traditional carotenoid formulations (ISRCTN clinical trial registration number: ISRCTN18206561).

Item Type:	Article
Additional Information:	Funding Information: Funding: This trial was funded by the Howard Foundation UK (Registered UK Charity Number: 285822) and via the Waterford Institute of Technology (WIT) President’s scholarship program in partnership Industrial Organica, Mexico. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/1300/1303
Departments or Groups:
Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:01
Last Modified:	05 Aug 2023 19:10
URI:	http://repository-testing.wit.ie/id/eprint/3631

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