The impact of macular pigment augmentation on visual performance in normal subjects : COMPASS

Nolan, John M. and Loughman, James and Akkali, Mukunda C. and Stack, Jim and Scanlon, Grainne and Davison, Peter and Beatty, Stephen (2011) The impact of macular pigment augmentation on visual performance in normal subjects : COMPASS. Vision Research, 51 (5). pp. 459-469. ISSN 0042-6989

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This study was conducted to investigate whether augmentation of macular pigment (MP) enhances visual performance (VP). 121 normal subjects were recruited. The active (A) group consumed 12. mg of lutein (L) and 1. mg of zeaxanthin (Z) daily. MP optical density (MPOD) was assessed by customized heterochromatic flicker photometry. VP was assessed as best corrected visual acuity (BCVA), mesopic and photopic contrast sensitivity (CS), glare disability, photostress, and subjective visual function. Subjects were assessed at baseline; 3; 6; 12. months (V1, V2, V3 and V4, respectively). Central MPOD increased significantly in the A group (p< 0.05) but not in the placebo group (p> 0.05). This statistically significant increase in MPOD in the A group was not, in general, associated with a corresponding improvement in VP (p> 0.05, for all variables), with the exception of a statistically significant time/treatment effect in " daily tasks comparative analysis" (p= 0.03). At V4, we report statistically significant differences in mesopic CS at 20.7. cpd, mesopic CS at 1.5. cpd under high glare conditions, and light/dark adaptation comparative analysis between the lower and the upper MP tertile groups (p< 0.05) Further study into the relationship between MP and VP is warranted, with particular attention directed towards individuals with low MP and suboptimal VP.

Item Type: Article
Additional Information: Funding Information: Study supported by Bausch & Lomb Inc. and Enterprise Ireland, under the Innovation Partnerships Programme.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2700/2731
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:01
Last Modified: 23 Jul 2023 02:00

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