Thermal desorption characterisation of molecularly imprinted polymers. Part II : Use of direct probe GC-MS analysis to study crosslinking effects

Holland, Niamh and Duggan, Patrick and Owens, Eleanor and Cummins, Wayne and Frisby, June and Hughes, Helen and McLoughlin, Peter (2008) Thermal desorption characterisation of molecularly imprinted polymers. Part II : Use of direct probe GC-MS analysis to study crosslinking effects. Analytical and Bioanalytical Chemistry, 391 (4). pp. 1245-1253. ISSN 1618-2642

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Abstract

A powerful method utilising direct probe thermal desorption GC-MS is presented for the study of molecularly imprinted polymers (MIPs). A series of 2-aminopyridine (2-apy)-imprinted methacrylic acid-ethyleneglycol dimethacrylate (MAA-EGDMA) copolymers were prepared under identical conditions but with varying amounts of EGDMA (crosslinking monomer). The use of appropriate temperature programmes permitted template removal, and the subsequent assessment of polymer affinity and specificity, all of which were found to be dependent on polymer composition and morphology. The system was sufficiently sensitive to identify a specific response of imprinted polymers over nonimprinted counterparts. Correlations were found to exist between thermal desorption analysis and solution phase binding, which was assessed by UV spectroscopy, where specificity was found to diminish with decreasing EGDMA concentration. This was attributed to the increased number of free carboxyl groups in those polymers containing a lower percentage of EGDMA. Thermal desorption profiles obtained for the analyte were found to be unaffected by the physical and chemical properties of the solvent used for analyte reloading.

Item Type:	Article
Additional Information:	Funding Information: Acknowledgements Financial support from Council of Directors, under the Technology Sector Strand 1, and the European Union’s INTERREG IIIA (SWINGS project) programme is gratefully acknowledged. Nitrogen sorption porosity analysis carried out by the Welsh School of Pharmacy, Cardiff, UK, is gratefully acknowledged.
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/1600/1602
Departments or Groups:
Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:01
Last Modified:	07 Jun 2023 18:41
URI:	http://repository-testing.wit.ie/id/eprint/3655

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