Supplementation with three different macular carotenoid formulations in patients with early age-related macular degeneration

Sabour-Pickett, Sarah and Beatty, Stephen and Connolly, Eithne and Loughman, James and Stack, Jim and Howard, Alan and Klein, Ronald and Klein, Barbara E. and Meuer, Stacy M. and Myers, Chelsea E. and Akuffo, Kwadwo O. and Nolan, John M. (2014) Supplementation with three different macular carotenoid formulations in patients with early age-related macular degeneration. Retina, 34 (9). pp. 1757-1766. ISSN 0275-004X

Full text not available from this repository. (Request a copy)

Abstract

PURPOSE:: To investigate the impact of three different macular carotenoid formulations on macular pigment optical density and visual performance in subjects with early age-related macular degeneration. METHODS:: Fifty-two subjects were supplemented and followed for 12 months, 17 of them were in intervention Group 1 (20 mg/day lutein and 2 mg/day zeaxanthin); 21 in Group 2 (10 mg/day meso-zeaxanthin, 10 mg/day lutein, and 2 mg/day zeaxanthin); and 14 in Group 3 (17 mg/day meso-zeaxanthin, 3 mg/day lutein, and 2 mg/day zeaxanthin). The macular pigment optical density was measured using customized heterochromatic flicker photometry, and visual function was assessed using corrected distance visual acuity and by letter contrast sensitivity. RESULTS:: A statistically significant increase in the macular pigment optical density was observed at all measured eccentricities in Group 2 (P ≤ 0.005) and in Group 3 (P < 0.05, for all), but only at 1.75° in Group 1 (P = 0.018). Statistically significant (P < 0.05) improvements in letter contrast sensitivity were seen at all spatial frequencies (except 1.2 cycles per degree) in Group 3, and at low spatial frequencies in Groups 1 and 2. CONCLUSION:: Augmentation of the macular pigment optical density across its spatial profile and enhancements in contrast sensitivity were best achieved after supplementation with a formulation containing high doses of meso-zeaxanthin in combination with lutein and zeaxanthin.

Item Type:	Article
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/2700/2731
Departments or Groups:
Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:02
Last Modified:	21 Jun 2023 18:36
URI:	http://repository-testing.wit.ie/id/eprint/3686

Actions (login required)

View Item