Inclusion of magnetic dipole-dipole and hydrodynamic interactions in implant-assisted magnetic drug targeting

Cregg, P. J. and Murphy, Kieran and Mardinoglu, Adil (2009) Inclusion of magnetic dipole-dipole and hydrodynamic interactions in implant-assisted magnetic drug targeting. Journal of Magnetism and Magnetic Materials, 321 (23). pp. 3893-3898. ISSN 0304-8853

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Abstract

Mathematical modelling of the implant-assisted magnetic drug targeting system of Avilés, Ebner and Ritter is performed. In order to model the agglomeration of particles known to occur in this system, the magnetic dipole-dipole and hydrodynamic interactions are included. Such interactions were calculated previously by Mikkelsen et al. under low magnetic fields (~0.05 T) in microfluidic systems. Here, a higher magnetic field (0.7 T) is considered and the effect of interactions on two nanoparticles with a seed implant is calculated. The calculations were performed with the open-source software OpenFOAM. Different initial positions are considered and the system performance is assessed in terms of capture cross section. Inclusion of both interactions was seen to alter the capture cross section of the system by up to 7% in absolute terms.

Item Type: Article
Additional Information: Funding Information: This work was funded by Enterprise Ireland under the Applied Research Enhancement (ARE) program as part of the South Eastern Applied Materials (SEAM) Research Centre. Dr Adriele Prina-Mello of CRANN, Trinity College Dublin is thanked for assistance at the 7th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, May 2008 in Vancouver. AM is grateful to the conference organisers for free registration.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2500/2504
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:03
Last Modified: 07 Jun 2023 18:42
URI: http://repository-testing.wit.ie/id/eprint/3833

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