O'Connell, Eamonn D. and Nolan, John M. and Stack, Jim and Greenberg, David and Kyle, Janet and Maddock, Leigh Anne and Beatty, Stephen (2008) Diet and risk factors for age-related maculopathy. American Journal of Clinical Nutrition, 87 (3). pp. 712-722. ISSN 0002-9165
Full text not available from this repository. (Request a copy)Abstract
Background: Evidence continues to accumulate that oxidative stress is etiologically important in the pathogenesis of age-related maculopathy (ARM) and that appropriate antioxidants of dietary origin may protect against this condition. Objective: Risk factors for ARM may be classed as established or putative. We report a study designed to investigate whether such risk factors are associated with a dietary lack of antioxidants relevant to retinal health. Design: Dietary, anthropometric, and sociodemographic details relating to 828 healthy Irish subjects aged 20-60 y were recorded in a cross-sectional fashion and analyzed for associations between risk factors for ARM and dietary intake of relevant nutrients. Results: Of the established risk factors for ARM, increasing age was associated with a relative lack of dietary zeaxanthin (P < 0.05) and tobacco use with a relative lack of dietary vitamin C (P < 0.05). Of the putative risk factors for ARM, alcohol consumption was associated with a relative lack of dietary α-linoleic acid (P < 0.05), and female sex was associated with a relative lack of dietary zinc (P < 0.05). Conclusions: We showed that several variables related to risk for ARMare associated with a relative dietary lack of key nutrients. Our finding that age, the most important and universal risk factor for ARM, is associated with a relative lack of dietary zeaxanthin, is an important finding that warrants further investigation.
Item Type: | Article |
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Uncontrolled Keywords: | /dk/atira/pure/subjectarea/asjc/2700/2701 |
Departments or Groups: | |
Depositing User: | Admin SSL |
Date Deposited: | 19 Oct 2022 23:04 |
Last Modified: | 23 Jun 2023 16:05 |
URI: | http://repository-testing.wit.ie/id/eprint/3871 |
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