Vitreous antioxidants, degeneration, and vitreo-retinopathy : Exploring the links

Ankamah, Emmanuel and Sebag, J. and Ng, Eugene and Nolan, John M. (2020) Vitreous antioxidants, degeneration, and vitreo-retinopathy : Exploring the links. Antioxidants, 9 (1). ISSN 2076-3921

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The transparent vitreous body, which occupies about 80% of the eye’s volume, is laden with numerous enzymatic and non-enzymatic antioxidants that could protect the eye from oxidative stress and disease. Aging is associated with degeneration of vitreous structure as well as a reduction in its antioxidant capacity. A growing body of evidence suggests these age-related changes may be the precursor of numerous oxidative stress-induced vitreo-retinopathies, including vision degrading myodesopsia, the clinically significant entoptic phenomena that can result from advanced vitreous degeneration. Adequate intravitreal antioxidant levels may be protective against vitreous degeneration, possibly preventing and even improving vision degrading myodesopsia as well as mitigating various other vitreo-retinopathies. The present article is, therefore, a review of the different antioxidant molecules within vitreous and the inter-relationships between vitreous antioxidant capacity and degeneration.

Item Type: Article
Additional Information: Funding Information: Funding: This work was supported by funds from Waterford Institute of Technology (WIT) and ebiga-VISION GmbH through the WIT PhD Co-Fund Scholarship (WD_2017_43). Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1300/1303
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:04
Last Modified: 16 Aug 2023 03:25

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