Synthesis of mucoadhesive thiolated gelatin using a two-step reaction process

Duggan, Sarah and O'Donovan, Orla and Owens, Eleanor and Cummins, Wayne and Hughes, Helen (2015) Synthesis of mucoadhesive thiolated gelatin using a two-step reaction process. European Journal of Pharmaceutics and Biopharmaceutics, 91. pp. 75-81. ISSN 0939-6411

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Using a novel two-step approach, the thiolation of gelatin for mucoadhesive drug delivery has been achieved. The initial step involved the amination of native gelatin via an amine to carboxylic acid coupling reaction with ethylene diamine, followed by thiolation with Traut's reagent. The resulting thiolated product showed an increase in thiol content of up to 10-fold in comparison with control gelatin samples. Improved cohesion and mucoadhesion in comparison with unmodified and control gelatin samples was also observed. This reaction process was observed to be influenced by both the temperature and the pH of the amination reaction, affecting both amine content and product yield. Swelling ability, cohesion and mucoadhesion were all observed to be strongly dependent on the thiol content of the samples but also, importantly, the molecular weight (MW) of the gelatin used. Gelatin with a MW of 20-25 kDa proved to be optimal in creating this novel mucoadhesive gelatin material.

Item Type: Article
Additional Information: Publisher Copyright: © 2015 Elsevier B.V. All rights reserved.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1300/1305
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:04
Last Modified: 01 Aug 2023 22:25

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