Concordance of macular pigment measurement using customized heterochromatic flicker photometry and fundus autofluorescence in age-related macular degeneration

Akuffo, Kwadwo Owusu and Beatty, Stephen and Stack, Jim and Peto, Tunde and Leung, Irene and Corcoran, Laura and Power, Rebecca and Nolan, John M. (2015) Concordance of macular pigment measurement using customized heterochromatic flicker photometry and fundus autofluorescence in age-related macular degeneration. Investigative Ophthalmology and Visual Science, 56 (13). pp. 8207-8214. ISSN 0146-0404

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Abstract

PURPOSE. We compared macular pigment (MP) measurements using customized heterochromatic flicker photometry (Macular Metrics Densitometer) and dual-wavelength fundus autofluorescence (Heidelberg Spectralis HRA + OCT MultiColor) in subjects with early age-related macular degeneration (AMD).METHODS. Macular pigment was measured in 117 subjects with early AMD (age, 44-88 years) using the Densitometer and Spectralis, as part of the Central Retinal Enrichment Supplementation Trial (CREST; ISRCTN13894787). Baseline and 6-month study visits data were used for the analyses. Agreement was investigated at four different retinal eccentricities, graphically and using indices of agreement, including Pearson correlation coefficient (precision), accuracy coefficient, and concordance correlation coefficient (ccc). RESULTS. Agreement was poor between the Densitometer and Spectralis at all eccentricities, at baseline (e.g., at 0.25° eccentricity, accuracy = 0.63, precision = 0.35, ccc = 0.22) and at 6 months (e.g., at 0.25° eccentricity, accuracy = 0.52, precision = 0.43, ccc = 0.22). Agreement between the two devices was significantly greater for males at 0.5° and 1.0° of eccentricity. At all eccentricities, agreement was unaffected by cataract grade. CONCLUSIONS. In subjects with early AMD, MP measurements obtained using the Densitometer and Spectralis are not statistically comparable and should not be used interchangeably in either the clinical or research setting. Despite this lack of agreement, statistically significant increases in MP, following 6 months of supplementation with macular carotenoids, were detected with each device, confirming that these devices are capable of measuring change in MP within subjects over time. (http://www.controlled-trials.com number, ISRCTN13894787.).

Item Type:	Article
Additional Information:	Publisher Copyright: © 2015 The Association for Research in Vision and Ophthalmology, Inc.
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/2700/2731
Departments or Groups:
Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:04
Last Modified:	02 Jul 2023 06:20
URI:	http://repository-testing.wit.ie/id/eprint/3933

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