Molecularly imprinted polymers for corticosteroids : Impact of polymer format on recognition behaviour

Fitzhenry, Laurence and Manesiotis, Panagiotis and Duggan, Patrick and McLoughlin, Peter (2013) Molecularly imprinted polymers for corticosteroids : Impact of polymer format on recognition behaviour. Microchimica Acta, 180 (15-16). pp. 1421-1431. ISSN 0026-3672

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A comparative study was performed on different polymeric formats for targeting corticosteroids, focusing on the use of bulk monolith and precipitation polymerisation strategies. Hydrocortisone-17-butyrate was selected as the template and methacrylic acid as the functional monomer, following 1H NMR investigation of the pre-polymerisation mixture. Three different cross-linkers were tested, ranging from moderate to highly hydrophobic. The synthesised bulk and precipitated imprinted polymers were physically characterised by nitrogen sorption and evaluated by means of HPLC and frontal chromatography against a range of template analogues. While some degree of selectivity for the template was achieved for all tested polymers, the ones based on the tri-functional cross-linking monomer trimethylolpropane trimethacrylate exhibited the longest retention for all corticosteroids, especially in the precipitated format, which suggested broader group selectivity. [Figure not available: see fulltext.]

Item Type: Article
Additional Information: Funding Information: The authors gratefully acknowledge the funding provided by Enterprise Ireland, under the Technology Gateway Programme, the Irish Research Council for Science, Engineering and Technology, under the Embark Initiative and the Technological Sector Research under the Strand III programme.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1600/1602
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:05
Last Modified: 07 Jun 2023 18:43

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