Many particle magnetic dipole-dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting

Cregg, P. J. and Murphy, Kieran and Mardinoglu, Adil and Prina-Mello, Adriele (2010) Many particle magnetic dipole-dipole and hydrodynamic interactions in magnetizable stent assisted magnetic drug targeting. Journal of Magnetism and Magnetic Materials, 322 (15). pp. 2087-2094. ISSN 0304-8853

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Abstract

The implant assisted magnetic targeted drug delivery system of Avilés, Ebner and Ritter is considered both experimentally (in vitro) and theoretically. The results of a 2D mathematical model are compared with 3D experimental results for a magnetizable wire stent. In this experiment a ferromagnetic, coiled wire stent is implanted to aid collection of particles which consist of single domain magnetic nanoparticles (radius ≈ 10 nm). In order to model the agglomeration of particles known to occur in this system, the magnetic dipole-dipole and hydrodynamic interactions for multiple particles are included. Simulations based on this mathematical model were performed using open source C++ code. Different initial positions are considered and the system performance is assessed in terms of collection efficiency. The results of this model show closer agreement with the measured in vitro experimental results and with the literature. The implications in nanotechnology and nanomedicine are based on the prediction of the particle efficiency, in conjunction with the magnetizable stent, for targeted drug delivery.

Item Type:	Article
Additional Information:	Funding Information: This work was funded by Enterprise Ireland under the Applied Research Enhancement (ARE) program as part of the South Eastern Applied Materials (SEAM) Research Centre at Waterford Institute of Technology. AM would like to thank Maurice Curtin for his help during the experiment in CRANN. Dr Prina-Mello would also like to thank Science Foundation Ireland (SFI), and CRANN for the financial support and Cetoni Gmbh for their technical support.
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/2500/2504
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Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:05
Last Modified:	07 Jun 2023 18:43
URI:	http://repository-testing.wit.ie/id/eprint/3955

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