Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis

Crespo-Piazuelo, Daniel and Lawlor, Peadar G. and Ranjitkar, Samir and Cormican, Paul and Villodre, Carmen and Bouwhuis, Meike A. and Marsh, Alan and Crispie, Fiona and Rattigan, Ruth and Gardiner, Gillian E. (2021) Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis. Scientific Reports, 11 (1). ISSN 2045-2322

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Abstract

The objective was to evaluate the effect of dietary Bacillus altitudinis spore supplementation during day (D)0–28 post-weaning (PW) and/or D29–56 PW compared with antibiotic and zinc oxide (AB + ZnO) supplementation on pig growth and gut microbiota. Eighty piglets were selected at weaning and randomly assigned to one of five dietary treatments: (1) negative control (Con/Con); (2) probiotic spores from D29–56 PW (Con/Pro); (3) probiotic spores from D0–28 PW (Pro/Con); (4) probiotic spores from D0–56 PW (Pro/Pro) and (5) AB + ZnO from D0–28 PW. Overall, compared with the AB + ZnO group, the Pro/Con group had lower body weight, average daily gain and feed intake and the Pro/Pro group tended to have lower daily gain and feed intake. However, none of these parameters differed between any of the probiotic-treated groups and the Con/Con group. Overall, AB + ZnO-supplemented pigs had higher Bacteroidaceae and Prevotellaceae and lower Lactobacillaceae and Spirochaetaceae abundance compared to the Con/Con group, which may help to explain improvements in growth between D15–28 PW. The butyrate-producing genera Agathobacter, Faecalibacterium and Roseburia were more abundant in the Pro/Con group compared with the Con/Con group on D35 PW. Thus, whilst supplementation with B. altitudinis did not enhance pig growth performance, it did have a subtle, albeit potentially beneficial, impact on the intestinal microbiota.

Item Type:	Article
Additional Information:	Funding Information: We thank Tomas Ryan, Florence Viard, Eoghan Gubbins-Cloney and the farm staff in the Pig Development Department at Teagasc Moorepark for assistance with the pig study. We also acknowledge Rebecca Ham, Renz Ybanez, Thomas Byrne and John Phelan (Waterford Institute of Technology); Laura Finnegan and David Clarke (Teagasc) for technical assistance; and Jim O’Donovan (Department of Agriculture Food and the Marine) for haematology analysis. The project leading to these results was co-funded by Enterprise Ireland and the European Regional Development Fund (ERDF) under Ireland’s European Structural and Investment Funds Programme 2014-2020. Thomas Byrne who provided technical assistance was funded by a Students into Work grant from the Society for Applied Microbiology. Publisher Copyright: © 2021, The Author(s).
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/1000
Departments or Groups:
Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:05
Last Modified:	26 Jul 2023 21:45
URI:	http://repository-testing.wit.ie/id/eprint/3959

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