Host-microbiota interactions in ileum and caecum of pigs divergent in feed efficiency contribute to nutrient utilization

Reyer, Henry and Oster, Michael and McCormack, Ursula M. and Muráni, Eduard and Gardiner, Gillian E. and Ponsuksili, Siriluck and Lawlor, Peadar G. and Wimmers, Klaus (2020) Host-microbiota interactions in ileum and caecum of pigs divergent in feed efficiency contribute to nutrient utilization. Microorganisms, 8 (4). ISSN 2076-2607

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Abstract

The composition of the intestinal microbiota plays an important role in the digestion and utilization of nutrients and for gut health. Low-fiber diets stimulate digestion and absorption processes, predominantly in the upper region of the gastrointestinal tract, thereby increasing the conversion of feed into body weight. As a consequence, the chemical composition of digesta after duodenal and jejunal absorption processes and passage has a limited complexity affecting colonization and molecular profiles of enterocytes in the hind gut. To decipher ileal and caecal microbial ecosystems and host transcriptional profiles that are beneficial for effective use of the remaining nutrients, pigs differing in feeding efficiency were studied. Biological functions that were consistently enriched at both the gene and microbiota levels comprise immunity-related processes, which ensure the integrity of the gastrointestinal tract. In addition, the differential abundance of certain genera, including Rothia, Subdoligranulu, Leeia and Cellulosilyticum, reflects the establishment of a microbial profile that supports the digestion of endogenously indigestible dietary components in highly feed-efficient pigs. Overall, the results indicate the potential to promote these beneficial functions and further improve feed efficiency through manipulation of dietary and probiotic strategies.

Item Type: Article
Additional Information: Funding Information: Funding: This research was funded by the European Union Seventh Framework Programme (FP7/2007–2013) as part of the ECO-FCE project under grant agreement No. 311794. Funding Information: This research was funded by the European Union Seventh Framework Programme (FP7/2007-2013) as part of the ECO-FCE project under grant agreement No. 311794. The authors thank Angela Garve, Annette Jugert and Nicole Gentz for their excellent technical help and the farm staff in the Pig Development Department at Teagasc Moorepark for assistance with pig management. This work was funded by the European Union Seventh Framework Programme (FP7/2007-2013) as part of the ECO-FCE project under grant agreement No. 311794. Publisher Copyright: © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2400/2404
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:05
Last Modified: 03 Aug 2023 01:40
URI: http://repository-testing.wit.ie/id/eprint/3964

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