From carotenoid intake to carotenoid blood and tissue concentrations-implications for dietary intake recommendations

Böhm, Volker and Lietz, Georg and Olmedilla-Alonso, Begonã and Phelan, David and Reboul, Emmanuelle and Bánati, Diana and Borel, Patrick and Corte-Real, Joana and De Lera, Angel R. and Desmarchelier, Charles and Dulinska-Litewka, Joanna and Landrier, Jean Francois and Milisav, Irina and Nolan, John and Porrini, Marisa and Riso, Patrizia and Roob, Johannes M. and Valanou, Elisavet and Wawrzyniak, Agata and Winklhofer-Roob, Brigitte M. and Rühl, Ralph and Bohn, Torsten (2021) From carotenoid intake to carotenoid blood and tissue concentrations-implications for dietary intake recommendations. Nutrition Reviews, 79 (5). pp. 544-573. ISSN 0029-6643

Full text not available from this repository. (Request a copy)


There is uncertainty regarding carotenoid intake recommendations, because positive and negative health effects have been found or are correlated with carotenoid intake and tissue levels (including blood, adipose tissue, and the macula), depending on the type of study (epidemiological vs intervention), the dose (physiological vs supraphysiological) and the matrix (foods vs supplements, isolated or used in combination). All these factors, combined with interindividual response variations (eg, depending on age, sex, disease state, genetic makeup), make the relationship between carotenoid intake and their blood/tissue concentrations often unclear and highly variable. Although blood total carotenoid concentrations <1000 nmol/L have been related to increased chronic disease risk, no dietary reference intakes (DRIs) exist. Although high total plasma/serum carotenoid concentrations of up to 7500 nmol/L are achievable after supplementation, a plateauing effect for higher doses and prolonged intake is apparent. In this review and position paper, the current knowledge on carotenoids in serum/plasma and tissues and their relationship to dietary intake and health status is summarized with the aim of proposing suggestions for a "normal,"safe, and desirable range of concentrations that presumably are beneficial for health. Existing recommendations are likewise evaluated and practical dietary suggestions are included.

Item Type: Article
Additional Information: Publisher Copyright: © 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the International Life Sciences Institute.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2700/2701
Departments or Groups:
Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:06
Last Modified: 15 Aug 2023 16:05

Actions (login required)

View Item View Item