Calculation of nanoparticle capture efficiency in magnetic drug targeting

Cregg, P. J. and Murphy, Kieran and Mardinoglu, Adil (2008) Calculation of nanoparticle capture efficiency in magnetic drug targeting. Journal of Magnetism and Magnetic Materials, 320 (23). pp. 3272-3275. ISSN 0304-8853

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Abstract

The implant assisted magnetic targeted drug delivery system of Avilés, Ebner and Ritter, which uses high gradient magnetic separation (HGMS) is considered. In this 2D model large ferromagnetic particles are implanted as seeds to aid collection of multiple domain nanoparticles (radius ≈ 200 nm). Here, in contrast, single domain magnetic nanoparticles (radius in 20-100 nm) are considered and the Langevin function is used to describe the magnetization. Simulations based on this model were performed using the open source C ++ finite volume library OpenFOAM. The simulations indicate that use of the Langevin function predicts greater collection efficiency than might be otherwise expected.

Item Type:	Article
Additional Information:	Funding Information: This work was funded by Enterprise Ireland under the Applied Research Enhancement (ARE) program as part of the South Eastern Applied Materials (SEAM) Research Centre at Waterford Institute of Technology. AM is grateful to Cancer Research Ireland (Irish Cancer Society) for an Oncology Scholars Travel Award to attend the 6th International Conference on the Scientific and Clinical Applications of Magnetic Carriers , May 2006 in Krems, Austria. PJC and AM thank Armin Ebner, Axel Rosengart & Misael Avilés for helpful conversations at Krems.
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/2500/2504
Departments or Groups:
Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:06
Last Modified:	07 Jun 2023 18:44
URI:	http://repository-testing.wit.ie/id/eprint/4089

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