Analysis of lutein, zeaxanthin, and meso-zeaxanthin in the organs of carotenoid-supplemented chickens

Phelan, David and Prado-Cabrero, Alfonso and Nolan, John M. (2018) Analysis of lutein, zeaxanthin, and meso-zeaxanthin in the organs of carotenoid-supplemented chickens. Foods, 7 (2). ISSN 2304-8158

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Abstract

The macular carotenoids (i.e., lutein (L), zeaxanthin (Z) and meso-zeaxanthin (MZ)) exhibit anti-inflammatory, antioxidant and optical properties that are believed to support human health and function. Studying the accumulation and distribution of these nutrients in tissues and organs, in addition to the eye, is an important step in understanding how these nutrients might support global human function and health (e.g., heart and brain). Chicken is an appropriate animal model with which to study the accumulation of these carotenoids in organs, as the relevant transport molecules and carotenoid binding proteins for L, Z and MZ are present in both humans and chickens. In this experiment, a sample of 3 chickens that were supplemented with L and MZ diacetate (active group) and a sample of 3 chickens that received a standard diet (control group) were analysed. Both groups were analysed for L, Z and MZ concentrations in the brain, eyes, heart, lung, duodenum/pancreas, jejunum/ileum, kidney and breast tissue. L, Z and MZ were identified in all the organs/tissues analysed from the active group. L and Z were identified in all of the organs/tissues analysed from the control group; while, MZ was identified in the eyes of these animals only. The discovery that MZ is accumulated in the tissues and organs of chickens supplemented with this carotenoid is important, given that it is known that a combination of L, Z and MZ exhibits superior antioxidant capacity when compared to any of these carotenoids in isolation.

Item Type: Article
Additional Information: Funding Information: Acknowledgments: The authors wish to acknowledge the Howard Foundation, (Registered UK Charity No: 285822), IOSA (Industrial Orgánica S.A., Monterrey, Nuevo León, Mexico), MacuHealth LLC™ (Birmingham, MI, USA) and Alliance Pharma plc (Chippenham, Wiltshire, UK) for the financial support of this research. The Principal Investigator (JN) is also funded by the European Research Council (CREST Grant No. 281096). Funding Information: Conflicts of Interest: D.P. is a Howard Fellow, and his research program is supported by the Howard Foundation (English Charity reg. number 285822) via a grant from IOSA (Industrial Orgánica S.A., Monterrey, Nuevo León, Mexico), MacuHealth LLC™ (Birmingham, MI, USA) and Alliance Pharma Plc. (Chippenham, Wiltshire, UK); all of the above organizations have an interest in commercially available supplements containing the macular carotenoids. A.P.-C. was the previous incumbent of the Howard fellowship within the NRCI, but currently has no conflict of interest. J.M.N. does consultancy work for nutraceutical companies as a director of Nutrasight Consultancy Ltd., Waterford, Ireland. The sponsors had no involvement in study design, collection, analysis or interpretation of data, in the writing of the manuscript or in the decision to submit the article for publication. Publisher Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1100/1106
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:07
Last Modified: 11 Aug 2023 01:35
URI: http://repository-testing.wit.ie/id/eprint/4193

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