Mardinoglu, Adil and Cregg, P. J. and Murphy, Kieran and Curtin, Maurice and Prina-Mello, Adriele (2011) Theoretical modelling of physiologically stretched vessel in magnetisable stent assisted magnetic drug targetingapplication. Journal of Magnetism and Magnetic Materials, 323 (3-4). pp. 324-329. ISSN 0304-8853
Full text not available from this repository. (Request a copy)Abstract
The magnetisable stent assisted magnetic targeted drug delivery system in a physiologically stretched vessel is considered theoretically. The changes in the mechanical behaviour of the vessel are analysed under the influence of mechanical forces generated by blood pressure. In this 2D mathematical model a ferromagnetic, coiled wire stent is implanted to aid collection of magnetic drug carrier particles in an elastic tube, which has similar mechanical properties to the blood vessel. A cyclic mechanical force is applied to the elastic tube to mimic the mechanical stress and strain of both the stent and vessel while in the body due to pulsatile blood circulation. The magnetic dipoledipole and hydrodynamic interactions for multiple particles are included and agglomeration of particles is also modelled. The resulting collection efficiency of the mathematical model shows that the system performance can decrease by as much as 10% due to the effects of the pulsatile blood circulation.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: AM would like to thank Telecommunications Software & Systems Group (TSSG) for the financial support and Dr. Prina-Mello would like to thank Science Foundation Ireland (SFI), and CRANN for the financial support. |
| Uncontrolled Keywords: | /dk/atira/pure/subjectarea/asjc/2500/2504 |
| Departments or Groups: | |
| Depositing User: | Admin SSL |
| Date Deposited: | 19 Oct 2022 23:07 |
| Last Modified: | 07 Jun 2023 18:44 |
| URI: | http://repository-testing.wit.ie/id/eprint/4209 |
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