Optimisation and use of water-in-oil MEEKC in pharmaceutical analysis

Broderick, Margo and Donegan, Sheila and Power, Joe and Altria, Kevin (2005) Optimisation and use of water-in-oil MEEKC in pharmaceutical analysis. Journal of Pharmaceutical and Biomedical Analysis, 37 (5). pp. 877-884. ISSN 0731-7085

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Water-in-oil microemulsion electrokinetic chromatography has been applied to the separation of a range of acids, bases and neutrals and is especially suitable for very water-insoluble drug compounds. A number of operating parameters were evaluated. An optimised set of operating conditions allowed separation of a range of pharmaceutical formulations containing water-insoluble compounds. A number of novel applications for W/O microemulsions were developed and ability to quantify drug contents in tablets and a cream was shown with good precision, detector linearity and accuracy. Comparison of obtained data with those determined from a HPLC method showed acceptable agreement.

Item Type: Article
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1600/1602
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:08
Last Modified: 12 Aug 2023 02:00
URI: http://repository-testing.wit.ie/id/eprint/4312

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