Enrichment of macular pigment enhances contrast sensitivity in subjects free of retinal disease : Central retinal enrichment supplementation trials - Report 1

Nolan, John M. and Power, Rebecca and Stringham, Jim and Dennison, Jessica and Stack, Jim and Kelly, David and Moran, Rachel and Akuffo, Kwadwo O. and Corcoran, Laura and Beatty, Stephen (2016) Enrichment of macular pigment enhances contrast sensitivity in subjects free of retinal disease : Central retinal enrichment supplementation trials - Report 1. Investigative Ophthalmology and Visual Science, 57 (7). pp. 3429-3439. ISSN 0146-0404

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Abstract

PURPOSE. The high-performance visual function associated with central vision is mediated by the macula (the central retina), which accumulates three diet-derived pigments (the carotenoids lutein [L], zeaxanthin [Z], and meso-zeaxanthin [MZ]). Our study sought to investigate the impact on visual function, including contrast sensitivity (CS), of supplementation with these naturally occurring carotenoids, in individuals with low retinal concentrations. METHODS. Subjects consumed daily a formulation containing 10 mg L, 2 mg Z, and 10 mg MZ (active group; n = 53) or placebo (n = 52) for a period of 12 months. Study visits were at baseline, 3, 6, and 12 months. Contrast sensitivity at 6 cycles per degree (cpd) was the primary outcome measure (POM). Secondary outcome measures included CS at other spatial frequencies, best-corrected visual acuity (BCVA), glare disability, photostress recovery, and light scatter. Macular pigment optical density (MPOD) was measured using dual-wavelength autofluorescence, and serum carotenoid concentrations were analyzed using high performance liquid chromatography (HPLC). RESULTS. Compared to placebo, statistically significant improvements from baseline CS were detected at 6 (P = 0.002) and 1.2 (P = 0.004) cpd in the active group. Additionally, improvements in CS were commensurate with the observed increases in retinal concentrations of these carotenoids (r = 0.342, P = 0.002 at 6 cpd). CONCLUSIONS. These results indicate that dietary fortification with the macular carotenoids can have meaningful effects on visual function.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2016, Association for Research in Vision and Ophthalmology Inc. All rights reserved.
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/2700/2731
Departments or Groups:
Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:09
Last Modified:	12 Aug 2023 19:25
URI:	http://repository-testing.wit.ie/id/eprint/4421

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