Enhancement and restriction of chain motion in polymer networks

Hudson, Sarah P. and Owens, Eleanor and Hughes, Helen and McLoughlin, Peter (2012) Enhancement and restriction of chain motion in polymer networks. International Journal of Pharmaceutics, 430 (1-2). pp. 34-41. ISSN 0378-5173

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Sevelamer carbonate, a polymeric drug, adsorbs phosphate ions from the gastro intestine of patients suffering from chronic kidney disease. Polymer chain mobility becomes critical during its manufacture and storage. How the polymer chain mobility in sevelamer carbonate is quantitatively controlled by small molecular species, in this case by water molecules and bicarbonate anions, is demonstrated here. Spin-lattice relaxation times of the protons in the hydrogel, detected by solid state NMR, are indicative of mobility within the polymer. They decreased with increasing water content but increased as the bicarbonate anion content increased. As the water content increased, the glass transition temperature decreased but increasing the bicarbonate anion content had the opposite effect. FTIR analysis indicated that the anions were involved in bonding while the water molecules were not. The stability and physicochemical properties of polymers during storage and formulation depend on the polymeric structure and the dynamic behaviour of the polymer chains.

Item Type: Article
Additional Information: Funding Information: Financial support by Enterprise Ireland and Genzyme (Grant No. IP-2008-0807 ) is gratefully acknowledged. Ashish Joshi and David O’Grady from Genzyme Waterford are also acknowledged for their support.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/3000/3003
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:10
Last Modified: 27 Jun 2023 07:05
URI: http://repository-testing.wit.ie/id/eprint/4435

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