Comparative End-to-End Analysis of Ca2+-Signaling-Based Molecular Communication in Biological Tissues

Taynnan Barros, Michael and Balasubramaniam, Sasitharan and Jennings, Brendan (2015) Comparative End-to-End Analysis of Ca2+-Signaling-Based Molecular Communication in Biological Tissues. IEEE Transactions on Communications, 63 (12). pp. 5128-5142. ISSN 0090-6778

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Calcium (Ca2+)-signaling-based molecular communication is a short-range communication process that diffuses and propagates ions between the cells of a tissue. The communication process is initiated via stimulation and amplification of the production of Ca2+ ions within a cell; these ions then diffuse through a physical connection between cells called a gap junction. Ca2+ signaling can be found in different classes of cell. In excitable cells, initiation of the Ca2+-signaling process is accompanied by an electrical component; for nonexcitable cell types, the electrical component is absent; while hybrid cells exhibit both behaviors. This paper provides a comparison and analysis of the communication behavior in tissues comprised three specific cell types that utilize Ca2+ signaling: epithelium cells (nonexcitable), smooth muscle cells (excitable), and astrocytes (hybrid). The analysis focuses on spatiotemporal Ca2+ concentration dynamics and how they are influenced by the intracellular signaling process, the molecular diffusion delay, the gain and capacity of the communication channel, as well as intracellular signaling interference. This analysis of the communication behavior in the context of tissues provides insights useful for, inter alia, the design of nanomachines that are situated within tissues and that use analysis of the communication channel to infer tissue health.

Item Type: Article
Additional Information: Publisher Copyright: © 2015 IEEE.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2200/2208
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:10
Last Modified: 23 Jul 2023 02:00

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