Plasma Lutein and Zeaxanthin Are Associated with Better Cognitive Function Across Multiple Domains in a Large Population-Based Sample of Older Adults : Findings from the Irish Longitudinal Study on Aging

Feeney, Joanne and O'Leary, Neil and Moran, Rachel and O'Halloran, Aisling M. and Nolan, John M. and Beatty, Stephen and Young, Ian S. and Kenny, Rose Anne (2017) Plasma Lutein and Zeaxanthin Are Associated with Better Cognitive Function Across Multiple Domains in a Large Population-Based Sample of Older Adults : Findings from the Irish Longitudinal Study on Aging. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 72 (10). pp. 1431-1436. ISSN 1079-5006

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Abstract

Background Low blood serum or plasma concentrations of the xanthophyll carotenoids lutein and zeaxanthin have been implicated in poorer cognitive health in older adults. However, equivocal results from smaller studies and clinical trials highlight the need for large population-based studies with comprehensive measures of cognitive function and adjustment for multiple confounders to examine such associations in more depth. Methods In the current study, we investigated the association between plasma lutein and zeaxanthin and domain-specific cognitive performance in 4,076 community-dwelling adults aged 50 years or older from The Irish Longitudinal Study on Ageing. Mixed-effects models were fitted with adjustment for demographic and socioeconomic factors, health conditions, and health behaviors. Results Higher plasma lutein and zeaxanthin were independently associated with better composite scores across the domains of global cognition, memory, and executive function. We also found evidence that higher plasma zeaxanthin, but not lutein, was associated with better processing speed. These associations were consistent across domains. Conclusions Further investigation of the prognostic value of carotenoid concentrations, and their changes, on cognition in similar population-based samples longitudinally is warranted.

Item Type:	Article
Additional Information:	Funding Information: This work was supported by The Atlantic Philanthropies, The Irish Government, Irish Life plc, The Centre for Ageing Research and Development in Ireland (CARDI), which became the Ageing Research and Development Division within the Institute of Public Health in Ireland (IPH) in September 2015 (authors J.F.  and A.M.O.H), Waterford Institute of Technology and Bayer Ireland (R.M.), and the European Research Council (J.M.N.) Publisher Copyright: © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/1300/1302
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Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:10
Last Modified:	06 Aug 2023 16:05
URI:	http://repository-testing.wit.ie/id/eprint/4488

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