Akuffo, K. O. and Nolan, J. M. and Howard, A. N. and Moran, R. and Stack, J. and Klein, R. and Klein, B. E. and Meuer, S. M. and Sabour-Pickett, S. and Thurnham, D. I. and Beatty, S. (2015) Sustained supplementation and monitored response with differing carotenoid formulations in early age-related macular degeneration. Eye (Basingstoke), 29 (7). pp. 902-912. ISSN 0950-222X
Full text not available from this repository. (Request a copy)Abstract
PurposeTo compare the impact of sustained supplementation using different macular carotenoid formulations on macular pigment (MP) and visual function in early age-related macular degeneration (AMD).Patients and methodsSixty-seven subjects with early AMD were randomly assigned to: Group 1 (20 mg per day lutein (L), 0.86 mg per day zeaxanthin (Z); Ultra Lutein), Group 2 (10 mg per day meso-zeaxanthin (MZ), 10 mg per day L, 2 mg per day Z; Macushield; Macuhealth), Group 3 (17 mg per day MZ, 3 mg per day L, 2 mg per day Z). MP was measured using customised heterochromatic flicker photometry and visual function was assessed by measuring contrast sensitivity (CS) and best-corrected visual acuity (BCVA). AMD was graded using the Wisconsin Age-Related Maculopathy Grading System (AREDS 11-step severity scale).ResultsAt 3 years, a significant increase in MP from baseline was observed in all groups at each eccentricity (P<0.05), except at 1.75° in Group 1 (P=0.160). Between 24 and 36 months, significant increases in MP at each eccentricity were seen in Group 3 (P<0.05 for all), and at 0.50° in Group 2 (P<0.05), whereas no significant increases were seen in Group 1 (P>0.05 for all). At 36 months, compared with baseline, the following significant improvements (P<0.05) in CS were observed: Group 2 - 1.2, 6, and 9.6 cycles per degree (c.p.d.); Group 1 - 15.15 c.p.d.; and Group 3 - 6, 9.6, and 15.15 c.p.d. No significant changes in BCVA, or progression to advanced AMD, were observed.ConclusionIn early AMD, MP can be augmented with a variety of supplements, although the inclusion of MZ may confer benefits in terms of panprofile augmentation and in terms of CS enhancement.
Item Type: | Article |
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Additional Information: | Funding Information: This study was funded by a grant from the Howard Foundation, Cambridge, UK. KOA and JMN (the principal investigator) are currently funded by the European Research Council (ERC), grant reference number: 281096. We would like to thank Industrial Orgánica and Macuvision Europe for providing the study supplements. Publisher Copyright: © 2015 Macmillan Publishers Limited. |
Uncontrolled Keywords: | /dk/atira/pure/subjectarea/asjc/2700/2731 |
Departments or Groups: | |
Depositing User: | Admin SSL |
Date Deposited: | 19 Oct 2022 23:10 |
Last Modified: | 07 Jul 2023 16:05 |
URI: | http://repository-testing.wit.ie/id/eprint/4517 |
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