Probing the recognition of molecularly imprinted polymer beads

Osmani, Qendresa and Hughes, Helen and McLoughlin, Peter (2012) Probing the recognition of molecularly imprinted polymer beads. Journal of Materials Science, 47 (5). pp. 2218-2227. ISSN 0022-2461

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A facile, robust and cost-effective suspension polymerisation methodology for the generation of ibuprofen molecularly imprinted polymers in bead formats was evaluated. Mineral oil was employed as the continuous phase whereby microdroplets of the pre-polymerisation mixture were formed through vigorous agitation, followed by photo-polymerisation resulting in formation of imprinted beads. For comparison purposes, irregular particles were also prepared from monolith polymers. Physical characteristics of the imprinted polymers were investigated using scanning electron microscope, particle size distribution, nitrogen sorption porosimetry and solvent swelling ratios, with subsequent correlation of these parameters to analyte rebinding performance. Overall, an increase in affinity was observed with decreasing the degree of cross-linking, however, specific rebinding was compromised. An inverse relationship between polymer affinity for the template and surface area was identified, while solvent swelling ratios were directly related to polymer affinity. Correlation between pre-polymerisation studies and polymer binding performance highlighted the significance of employing the polymerisation solvent in template rebinding in order to achieve superior recognition capabilities. Additionally, shape selectivity of binding sites was demonstrated by the decreased binding performance of template structural analogues to the imprinted polymer.

Item Type: Article
Additional Information: Funding Information: Acknowledgements This study is supported by the Irish Research Council for Science, Engineering and Technology (IRCSET) under the Embark Initiative. The authors gratefully acknowledge Dr P. Manesiotis for fruitful discussions and advice.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/2500
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:11
Last Modified: 22 Jun 2023 05:05

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