The Screening and Evaluation of Fucus serratus and Fucus vesiculosus Extracts against Current Strains of MRSA Isolated from a Clinical Hospital Setting

Higgins Hoare, Annabel and Tan, Shiau Pin and McLoughlin, Peter and Mulhare, Patrick and Hughes, Helen (2019) The Screening and Evaluation of Fucus serratus and Fucus vesiculosus Extracts against Current Strains of MRSA Isolated from a Clinical Hospital Setting. Scientific Reports, 9 (1). ISSN 2045-2322

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Abstract

Antimicrobial resistant strains of infection are afflicting clinical settings, driving the search for novel antimicrobial compounds. Naturally sourced bioactives, for instance those from seaweeds, have the potential to ameliorate this issue. As such, solvent extracts from the edible Irish seaweeds Fucus serratus and Fucus vesiculosus were screened for antimicrobial activity against 28 clinically isolated strains of MRSA, including one GISA (glycopeptide intermediate S. aureus) and two mecC gene containing strains. The water extract of F. vesiculosus was the most promising extract went on to be tested for biofilm prevention and disruption activity. The disk diffusion method was used to investigate the inhibition of the bacterial pathogens tested while MIC, MBC and biofilm disruption and prevention analyses were performed spectroscopically and by plate counts, respectively. Solvent extracts were found to have a wide array of antimicrobial activity against the strains tested, with the water extract from Fucus vesiculosus being the most promising. This extract was also found to both prevent and disrupt MRSA biofilms indicating the potential extract as new antimicrobials, and raising the possibility of their possible use in therapeutics.

Item Type: Article
Additional Information: Funding Information: This research was supported by funding provided by the Irish Research Council. The authors of this paper would like to thank University Hospital Waterford, who donated the pathogens for this work. Publisher Copyright: © 2019, The Author(s).
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1000
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:11
Last Modified: 07 Jun 2023 18:46
URI: http://repository-testing.wit.ie/id/eprint/4579

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