Doyle, Jennifer L. and Berry, Donagh P. and Veerkamp, Roel F. and Carthy, Tara R. and Walsh, Siobhan W. and Evans, Ross D. and Purfield, Deirdre C. (2020) Genomic Regions Associated With Skeletal Type Traits in Beef and Dairy Cattle Are Common to Regions Associated With Carcass Traits, Feed Intake and Calving Difficulty. Frontiers in Genetics, 11. ISSN 1664-8021
Full text not available from this repository.Abstract
Linear type traits describing the skeletal characteristics of an animal are moderately to strongly genetically correlated with a range of other performance traits in cattle including feed intake, reproduction traits and carcass merit; thus, type traits could also provide useful insights into the morphological differences among animals underpinning phenotypic differences in these complex traits. The objective of the present study was to identify genomic regions associated with five subjectively scored skeletal linear traits, to determine if these associated regions are common in multiple beef and dairy breeds, and also to determine if these regions overlap with those proposed elsewhere to be associated with correlated performance traits. Analyses were carried out using linear mixed models on imputed whole genome sequence data separately in 1,444 Angus, 1,129 Hereford, 6,433 Charolais, 8,745 Limousin, 1,698 Simmental, and 4,494 Holstein-Friesian cattle, all scored for the linear type traits. There was, on average, 18 months difference in age at assessment of the beef versus the dairy animals. While the majority of the identified quantitative trait loci (QTL), and thus genes, were both trait-specific and breed-specific, a large-effect pleiotropic QTL on BTA6 containing the NCAPG and LCORL genes was associated with all skeletal traits in the Limousin population and with wither height in the Angus. Other than that, little overlap existed in detected QTLs for the skeletal type traits in the other breeds. Only two QTLs overlapped the beef and dairy breeds; both QTLs were located on BTA5 and were associated with height in both the Angus and the Holstein-Friesian, despite the difference in age at assessment. Several detected QTLs in the present study overlapped with QTLs documented elsewhere that are associated with carcass traits, feed intake, and calving difficulty. While most breeding programs select for the macro-traits like carcass weight, carcass conformation, and feed intake, the higher degree of granularity with selection on the individual linear type traits in a multi-trait index underpinning the macro-level goal traits, presents an opportunity to help resolve genetic antagonisms among morphological traits in the pursuit of the animal with optimum performance metrics.
| Item Type: | Article |
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| Additional Information: | Funding Information: This work was funded in part by a research grant from Science Foundation Ireland, award number 14/IA/2576, as well as a research grant from Science Foundation Ireland and the Department of Agriculture, Food and the Marine on behalf of the Government of Ireland under the Grant 16/RC/3835 (VistaMilk, Dublin, Ireland). Funding Information: The authors would like to thank the 1000 Bull Genomes Consortium for the reference population used to impute genotypes to sequence. Funding. This work was funded in part by a research grant from Science Foundation Ireland, award number 14/IA/2576, as well as a research grant from Science Foundation Ireland and the Department of Agriculture, Food and the Marine on behalf of the Government of Ireland under the Grant 16/RC/3835 (VistaMilk, Dublin, Ireland). Publisher Copyright: © Copyright © 2020 Doyle, Berry, Veerkamp, Carthy, Walsh, Evans and Purfield. |
| Uncontrolled Keywords: | /dk/atira/pure/subjectarea/asjc/1300/1313 |
| Departments or Groups: | |
| Depositing User: | Admin SSL |
| Date Deposited: | 19 Oct 2022 23:11 |
| Last Modified: | 14 Aug 2023 16:05 |
| URI: | http://repository-testing.wit.ie/id/eprint/4586 |
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