The use of molecularly imprinted sol-gels in pharmaceutical separations

Olwill, Aisling and Hughes, Helen and O'Riordain, Micháel and McLoughlin, Peter (2004) The use of molecularly imprinted sol-gels in pharmaceutical separations. Biosensors and Bioelectronics, 20 (6). pp. 1045-1050. ISSN 0956-5663

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This paper illustrates the potential of the sol-gel process to imprint the pharmaceutical active - N-[N-[(1S)-1-carboxssy-3-phenylpropyl]-l-lysyl]-l- proline, (lisinopril dihydrate). This template exhibits unique difficulties such as limited solubility in non-polar and most polar porogens with multiple functionality evident in its 4 pKa values. Selectivity for this template was achieved using a 3-monomer sol-gel system utilising solid phase extraction (SPE). Analysis of the template and its related substances was achieved using HPLC. The effect of solvent polarity on the rebinding of the template was studied. Through optimisation of porogen and extraction solvent, the imprinted material (MIP) demonstrated enhanced selectivity, for the template, over a non-imprinted material (NIP). Selectivity was also illustrated for the original template over two of its related substances. The effect of starting monomer ratio on selectivity was studied to determine the interactions, which could best be exploited to further enhance selectivity.

Item Type: Article
Additional Information: Funding Information: This research was funded under the Technological Sector Research and Initiative (2001) (Strand III) supported by Merck, Sharpe & Dohme, Clonmel Ltd., Ireland. The help of Sharon Marx, Department of Physical Chemistry, Israel Institute for Biological Research, Ness-Ziona, 70450 Israel, in the initial stages of this work is also greatly appreciated.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1300/1305
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:12
Last Modified: 21 Jun 2023 18:36

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