Baru, Sarn Ii and Fitzhenry, Laurence and Matthews, Siobhan and Walsh, Philip and Marchese, Eric and Coffey, Austin (2021) Evaluation of sub and near critical carbon dioxide for low processing temperature of medical thermoplastic polyurethane. In: 2021 SPE Annual Technical Conference, ANTEC 2021, 2021-05-10 - 2021-05-21.
Full text not available from this repository. (Request a copy)Abstract
Incorporation of thermosensitive active pharmaceutical ingredients for manufacturing multifunctional polymeric medical device is still limited as they can be deteriorated in the hot-melt extrusion process. In this study, the potential of sub and near-critical carbon dioxide for use as a green plasticiser was investigated. Pellethane thermoplastic polyurethane was hot melt extruded and its thermal and rheological behaviour were evaluated. The resultant extrudates were characterised using parallel-plate rotational rheometry and differential scanning calorimetry. The process temperature decreased from 185 to 160 °C. The rheology indicated that the melt viscosity reduced to 36.36% and 40.04% at 600 and 1000 psi, respectively. The results indicate that the employment of scCO2 as a transient plasticiser is a viable aid to conventional hot-melt extrusion and offers more opportunities for thermosensitive drugs to be coextruded at lower processing temperatures.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Additional Information: | Publisher Copyright: © 2021 Society of Plastics Engineers. All rights reserved. |
| Uncontrolled Keywords: | /dk/atira/pure/subjectarea/asjc/1500 |
| Departments or Groups: | |
| Depositing User: | Admin SSL |
| Date Deposited: | 19 Oct 2022 23:13 |
| Last Modified: | 08 Feb 2023 19:39 |
| URI: | http://repository-testing.wit.ie/id/eprint/4735 |
Actions (login required)
 |
View Item |
Altmetric Rosette
Altmetric Rosette