Hydrogels for arterial modelling and tissue scaffolding

Dunne, Aimee and Coffey, Austin B. and Murphy, Niall and Walsh, Philip R. and Walsh, Rachel and Lyons, Seán (2014) Hydrogels for arterial modelling and tissue scaffolding. In: 72nd Annual Technical Conference of the Society of Plastics Engineers: The Plastics Conference, ANTEC 2014, 2014-04-28 - 2014-04-30.

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Abstract

Models of human blood vessels have many potential applications as aids in continuing research on new medical devices. The work detailed herein describes the development of a hydrogel material to mimic the mechanical and biological response of a range of human arteries. The developed hydrogels were characterized via swelling studies, differential calorimetry and spectroscopic techniques, while viscoelastic property measurement was investigated primarily using rheological testing methods. A range HEMA/NVP hydrogel materials were successfully developed with properties comparable to a range of arteries, namely, the thoracic and abdominal aorta with storage moduli (G′) varying from 43kPa to 64kPa depending on the formulation. This paper also describes the construction of a mathematical model for the viscoelastic properties of these materials, representing the time-dependent behaviour of the simulated areterial material when subjected to loading and unloading phenomena.

Item Type:	Conference or Workshop Item (Paper)
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/1500
Departments or Groups:
Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:13
Last Modified:	07 Feb 2023 00:00
URI:	http://repository-testing.wit.ie/id/eprint/4749

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