Early Developmental Programming of the Ovarian Reserve, Ovarian Function, and Fertility

Mossa, Francesca and Walsh, Siobhàn W. and Evans, Alex C.O. and Jimenez-Krassel, Fermin and Ireland, James J. (2017) Early Developmental Programming of the Ovarian Reserve, Ovarian Function, and Fertility. In: Animal Models and Human Reproduction :. wiley, pp. 91-108. ISBN 9781118881606

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The environment encountered during fetal life exerts a profound influence on development, physiological function, and risk of disease in adult life in mammals. Poor maternal nutrition, including micronutrient deficiencies, contributes to at least 20% of maternal deaths and it increases the probability of poor pregnancy outcomes such as intrauterine growth restriction, resulting in low birth weight, stunting, wasting, and mortality. Natural and artificial dietary components, as well as environmental chemicals, may interfere with the physiological action of hormones and many of these endocrine-disrupting compounds (EDC) act as steroid receptor agonists and antagonists. This chapter focuses on the impact of prenatal environmental challenges, specifically undernutrition, overnutrition, and EDC (excess testosterone, BPA) on fetal oogonia, follicle/oocyte numbers and oocyte quality, and on the ovarian reserve, ovarian function, and fertility in offspring of farm animals, rodents, and women. Maternal environmental factors that diminish size of the fetal ovarian reserve would be expected to also impair fertility of offspring.

Item Type: Book Section
Additional Information: Publisher Copyright: © 2017 by John Wiley & Sons, Inc. All rights reserved.
Uncontrolled Keywords: /dk/atira/pure/subjectarea/asjc/1100
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Depositing User: Admin SSL
Date Deposited: 19 Oct 2022 23:18
Last Modified: 07 Jun 2023 18:40
URI: http://repository-testing.wit.ie/id/eprint/5219

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