Analysis of Molecular Communications on the Growth Structure of Glioblastoma Multiforme

Awan, Hamdan and Odysseos, Andreani and Nicolaou, Niovi and Balasubramaniam, Sasitharan (2021) Analysis of Molecular Communications on the Growth Structure of Glioblastoma Multiforme. In: 2021 IEEE Global Communications Conference, GLOBECOM 2021 - Proceedings :. 2021 IEEE Global Communications Conference, GLOBECOM 2021 - Proceedings . Institute of Electrical and Electronics Engineers Inc., ESP. ISBN 9781728181042

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Abstract

In this paper we consider the influence of inter-cellular communication on the development and progression of Glioblastoma Multiforme (GBM), a grade IV malignant glioma which is defined by an interplay Grow i.e. self renewal and Go i.e. invasiveness potential of multiple malignant glioma stem cells. Firstly, we performed wet lab experiments with U87 malignant glioma cells to study the node-stem growth pattern of GBM. Next we develop a model accounting for the structural influence of multiple transmitter and receiver glioma stem cells resulting in the node-stem growth structure of GBM tumour. By using information theory we study different properties associated with this communication model to show that the growth of GBM in a particular direction (node to stem) is related to an increase in mutual information. We further show that information flow between glioblastoma cells for different levels of invasiveness vary at different points between node and stem. These findings are expected to contribute significantly in the design of future therapeutic mechanisms for GBM.

Item Type:	Book Section
Additional Information:	Funding Information: Material in this paper has been part of and is supported by the European Union EU-FET-Open H2020 Gladiator Project 828837. Publisher Copyright: © 2021 IEEE.
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/1700/1702
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Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:18
Last Modified:	11 Aug 2023 08:00
URI:	http://repository-testing.wit.ie/id/eprint/5239

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