The effect of haematocrit on cerebral perfusion and clinical status following carotid occlusion in the gerbil

Pollock, S. and Tsitsopoulos, P. and Harrison, M. J. (1982) The effect of haematocrit on cerebral perfusion and clinical status following carotid occlusion in the gerbil. Stroke, 13 (2). pp. 167-170. ISSN 0039-2499

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Abstract

The effect of haematocrit on the sequelae of carotid occlusion has been studied in the gerbil stroke model. In 72 animals one carotid artery was clipped. After 30 minutes, the area of cerebral hemisphere filling with a carbon suspension administered intravenously was measured on coronal brain slices and related to the haematocrit. Exchange transfusion of autologous packed red blood cells or plasma produced a haematocrit range of 26% to 59%. At high haematocrit a larger area of non perfusion was more commonly encountered, and the anterior cerebral artery territory was more frequently affected along with that of the middle cerebral. Fifty-seven animals had temporary occlusion of both carotid arteries. Survival was adversely affected at high haematocrit. The role of haematocrit in affecting the pathophysiology of cerebral ischaemia is discussed.

Item Type:	Article
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/2700/2728
Departments or Groups:
Depositing User:	Admin SSL
Date Deposited:	18 Jul 2023 00:05
Last Modified:	19 Jul 2023 18:38
URI:	http://repository-testing.wit.ie/id/eprint/5273

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