The influence of red blood-cells on platelet adhesiveness.

Harrison, M. J. and Mitchell, J. R. (1966) The influence of red blood-cells on platelet adhesiveness. The Lancet, 2 (7474). pp. 1163-1164. ISSN 0140-6736

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Additional Information: Funding Information: DISCUSSION Occlusion of neck vessels, whether by atheroma or as part surgical of treatment, has a seemingly unpredictable effect on R.C.B.F. The effect depends largely on the dis- position of the circle of Willis which, if its anatomy is normal, redistributes blood very efficiently. Anatomical anomalies are common, however, especially in patients with aneurysms. This strictly limits the value of con- clusions about R.C.B.F. based on pressure measurements or electromagnetic flowmeter readings carried out on the neck vessels. As Gibbs 1 pointed out a method is needed which measures cerebral blood-flow at capillary level, and this in effect is achieved by the inert-gas clearance method. The technique gives the surgeon an immediate guide in the theatre and will indicate both the efficiency of intra- cranial collaterals and whether a carotid steal is produced by common-carotid ligation. SUMMARY Regional cerebral blood-flow can be measured in the operating-theatre during carotid ligation by the inert-gas- clearance method. The gamma emissions of radioactive xenon-133 are detected through the intact skull after intracarotid injection. Comparison of the flow before and after temporary clamping of the internal and common carotid arteries in turn gives an indication of the risk to the cerebral circula- tion of permanent ligation of either artery. This work was supported by grants from the Medical Research Council and Scottish Hospital Endowments Research Trust, and the Wellcome Trust. Department of Neurosurgery, Institute of Neurological Sciences, Killearn Hospital, Glasgow Wellcome Surgical Research Laboratory and St. Mungo Department of Surgery (Royal Infirmary), University of Glasgow
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Date Deposited: 18 Jul 2023 00:05
Last Modified: 19 Jul 2023 18:38

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