Macular carotenoids and age-related maculopathy

O'Connell, E. and Neelam, K. and Nolan, John M and Eong, K. G. A. and Beatty, Stephen (2006) Macular carotenoids and age-related maculopathy. Annals Academy Of Medicine Singapore, 35 (11). pp. 821-830.

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Lutein (L) and zeaxanthin (Z) are concentrated at the macula, where they are collectively known as macular pigment (MP), and where they are believed to play a major role in protecting retinal tissues against oxidative stress. Whilst the exact pathogenesis of age-related maculopathy (ARM) remains unknown, the disruption of cellular processes by oxidative stress may play an important role. Manipulation of dietary intake of L and Z has been shown to augment MP, thereby raising hopes that dietary supplementation with these carotenoids might prevent, delay, or modify the course of ARM. This article discusses the scientific rationale supporting the hypothesis that L and Z are protective against ARM, and presents the recent evidence germane to this theory.

Item Type: Article
Additional Information: ISI Document Delivery No.: 121KJ English Review 0304-4602
Uncontrolled Keywords: lutein macular degeneration oxidative stress zeaxanthin Pigment optical-density oxidative stress alpha-tocopherol human retina dietary carotenoids tissue distribution lipid-peroxidation primate retinas protective role beta-carotene
Departments or Groups: Macular Pigment Research Group
Divisions: School of Science
Date Deposited: 31 May 2007 18:45
Last Modified: 22 Aug 2016 10:25

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