Dietary intervention with a targeted micronutrient formulation reduces the visual discomfort associated with vitreous degeneration

Ankamah, Emmanuel and Green-Gomez, Marina and Roche, Warren and Ng, Eugene and Welge-Lüßen, Ulrich and Kaercher, Thomas and Nolan, John M. (2021) Dietary intervention with a targeted micronutrient formulation reduces the visual discomfort associated with vitreous degeneration. Translational Vision Science and Technology, 10 (12). ISSN 2164-2591

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Abstract

Purpose: To investigate the impact of supplementation with a targeted micronutrient formulation on the visual discomfort associated with vitreous degeneration. Methods: In this clinical trial, 61 patients with symptomatic vitreous floaters were randomized to consume daily, the active supplement consisting of 125 mg L-lysine, 40 mg vitamin C, 26.3 mg Vitis vinifera extract, 5 mg zinc, and 100 mg Citrus aurantium or placebo for 6 months. Change in visual discomfort from floaters, assessed with the Floater Disturbance Questionnaire, was the primary outcome measure. Secondary outcome measures included best-corrected visual acuity, letter contrast sensitivity, photopic functional contrast sensitivity with positive and negative contrast polarity, and quantitative vitreous opacity areas. Results: After supplementation, the active group reported a significant decrease in their visual discomfort from floaters (P < 0.001), whereas the placebo group had no significant change in their visual discomfort (P = 0.416). At 6 months, there was a significant decrease in vitreous opacity areas in the active group (P < 0.001) and an insignificant increase in vitreous opacity areas in the placebo group (P = 0.081). Also, there was a significant improvement in photopic functional contrast sensitivity with positive contrast polarity in the active group after supplementation (P = 0.047). Conclusions: The findings of this study indicate improvements in vision-related quality of life and visual function of patients suffering from vitreous floaters after supplementation with a formulation of antioxidative and antiglycation micronutrients. Notably, these improvements were confirmed by the decrease in vitreous opacity areas in the active group. Translational Relevance: This targeted dietary intervention should be considered to support patients with symptomatic vitreous degeneration.

Item Type:	Article
Additional Information:	Funding Information: Funded by Waterford Institute of Technology (WIT) and ebiga-VISION GmbH through a WIT PhD Co-Fund Scholarship (WD_2017_43). There is a royalty agreement in place between ebiga-VISION GmbH and WIT based on the intellectual property and the patent submitted as part of the study. EA and JMN are listed as inventors on the patent application which is pending, and cannot disclose any conflict of interest at this point in time. Publisher Copyright: © 2021 The Authors.
Uncontrolled Keywords:	/dk/atira/pure/subjectarea/asjc/2200/2204
Departments or Groups:
Depositing User:	Admin SSL
Date Deposited:	19 Oct 2022 23:08
Last Modified:	29 Jul 2023 01:55
URI:	http://repository-testing.wit.ie/id/eprint/4276

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